![]() RACR technology can be employed in both a manufacturing setting to generate iCILs and in vivo to enable the selective expansion and survival of iCILs. A synthetic small molecule ligand then binds RACR to drive the differentiation and expansion of the iCILs. The RACR platform permits the production of immune effector cells, termed RACR-induced cytotoxic innate lymphocytes (iCILs), in the absence of exogenous cytokines and feeder cells by genetically modifying iPSC-derived progenitor cells to express the RACR synthetic cytokine receptor. Current approaches for differentiating induced pluripotent stem cells (iPSCs) into therapeutic immune cell types often requires expensive exogenous gamma-chain cytokines for expansion and survival, and often, the presence of feeder cells. On Friday, May 6 th, Dave Vereide, Ph.D., Senior Scientist at Umoja Biopharma, will give an oral presentation titled “A synthetic cytokine receptor platform for producing cytotoxic innate lymphocytes as ‘off-the-shelf’ cancer therapeutics.” The presentation will highlight Umoja’s rapamycin-activated cytokine receptor (RACR) platform which seeks to address current challenges in the cellular therapy space. SEATTLE, – Umoja Biopharma, Inc., an immuno-oncology company pioneering off-the-shelf, integrated therapeutics that reprogram immune cells in vivo for patients with solid and hematologic malignancies, announced today that it will have an oral presentation at the International Society for Cell and Gene Therapy (ISCT) Annual Meeting 2022, to be held May 4-7, 2022 in San Francisco, California.
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